MARC details
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| fixed length control field |
05028cam a22002417i 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150504s2015 flua b 001 0 eng |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781466573178 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.042015195 |
| Item number |
B8M3 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Burgess, Stephen |
| 9 (RLIN) |
328438 |
| 245 10 - TITLE STATEMENT |
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| Title |
Mendelian randomization: methods for using genetic variants in causal estimation |
| Statement of responsibility, etc. |
Burgess, Stephen |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Boca Raton |
| Name of publisher, distributor, etc. |
CRC Press |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xiv, 210 p. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
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| Title |
Chapman and Hall/CRC interdisciplinary statistics series |
| 9 (RLIN) |
328447 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Table of Contents:<br/><br/><br/>I USING GENETIC VARIANTS AS INSTRUMENTAL VARIABLES TO ASSESS CAUSAL RELATIONSHIPS<br/><br/><br/>1. Introduction and motivation<br/>Shortcomings of classical epidemiology<br/>The rise of genetic epidemiology<br/>Motivating example: The inflammation hypothesis<br/>Other examples of Mendelian randomization<br/>Overview of book<br/>Summary<br/><br/>2. What is Mendelian randomization?<br/>What is Mendelian randomization?<br/>Why use Mendelian randomization?<br/>A brief overview of genetics<br/>Summary<br/><br/>3. Assumptions for causal inference<br/>Observational and causal relationships<br/>Finding a valid instrumental variable<br/>Testing for a causal relationship<br/>Estimating a causal effect<br/>Summary<br/><br/>4. Methods for instrumental variable analysis<br/>Ratio of coefficients method<br/>Two-stage methods<br/>Likelihood-based methods<br/>Semi-parametric methods<br/>Efficiency and validity of instruments<br/>Computer implementation<br/>Summary<br/><br/>5. Examples of Mendelian randomization analysis<br/>Fibrinogen and coronary heart disease<br/>Adiposity and blood pressure<br/>Lipoprotein(a) and myocardial infarction<br/>High-density lipoprotein cholesterol and myocardial infarction<br/>Discussion<br/><br/>6. Generalizability of estimates from Mendelian randomization<br/>Internal and external validity<br/>Comparison of estimates<br/>Discussion<br/>Summary<br/><br/><br/>II STATISTICAL ISSUES IN INSTRUMENTAL VARIABLE ANALYSIS AND MENDELIAN RANDOMIZATION<br/><br/><br/>7. Weak instruments and finite-sample bias<br/>Introduction<br/>Demonstrating the bias of IV estimates<br/>Explaining the bias of IV estimates<br/>Properties of IV estimates with weak instruments<br/>Bias of IV estimates with different choices of IV<br/>Minimizing the bias of IV estimates<br/>Discussion<br/>Key points from chapter<br/><br/>8. Multiple instruments and power<br/>Introduction<br/>Allele scores<br/>Power of IV estimates<br/>Multiple variants and missing data<br/>Discussion<br/>Key points from chapter<br/><br/>9. Multiple studies and evidence synthesis<br/>Introduction<br/>Assessing the causal relationship<br/>Study-level meta-analysis<br/>Summary-level meta-analysis<br/>Individual-level meta-analysis<br/>Example: C-reactive protein and fibrinogen<br/>Binary outcomes<br/>Discussion<br/>Key points from chapter<br/><br/>10. Example: The CRP CHD Genetics Collaboration<br/>Overview of the dataset<br/>Single study: Cardiovascular Health Study<br/>Meta-analysis of all studies<br/>Discussion<br/>Key points from chapter<br/><br/><br/>III PROSPECTS FOR MENDELIAN RANDOMIZATION<br/><br/><br/>11. Future directions<br/>Methodological developments<br/>Applied developments<br/>Conclusion<br/><br/>Bibliography<br/><br/>Index<br/><br/><br/> |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization spanning epidemiology, statistics, genetics, and econometrics. Although the book mainly focuses on epidemiology, much of the material can be applied to other areas of research.<br/><br/>Through several examples, the first part of the book shows how to perform simple applied Mendelian randomization analyses and interpret their results. The second part addresses specific methodological issues, such as weak instruments, multiple instruments, power calculations, and meta-analysis, relevant to practical applications of Mendelian randomization. In this part, the authors draw on data from the C-reactive protein Coronary heart disease Genetics Collaboration (CCGC) to illustrate the analyses. They present the mathematics in an easy-to-understand way by using nontechnical language and reinforcing key points at the end of each chapter. The last part of the book examines the potential of Mendelian randomization in the future, exploring both methodological and applied developments.<br/><br/>This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses. Chapter summaries, paper summaries, web-based applications, and software code for implementing the statistical techniques are available on a supplementary website.<br/><br/><br/>(https://www.crcpress.com/Mendelian-Randomization-Methods-for-Using-Genetic-Variants-in-Causal-Estimation/Burgess-Thompson/9781466573178)<br/> |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medical genetics - Statistical methods |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Mendelian randomization analysis - methods |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Genetic Variation |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Statistics as topic - methods |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Medical genetics - Statistical methods |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Thompson, Simon G. |
| 9 (RLIN) |
328443 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Book |
